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RNP world
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The RNP world is a hypothesized intermediate period in the origin of life characterized by the primary metabolic role of ribonucleoproteins. The period followed the hypothesized and ended with the formation of and contemporary proteins. In the RNP world, RNA molecules began to synthesize . These would eventually become which have since assumed most of the diverse functions RNA performed previously. This transition paved the way for DNA to replace RNA as the primary store of genetic information, leading to life as we know it.


Principle of concept
, in 2009, proposed the existence of the RNP world after his observation of apparent differences in the composition of in the two most fundamental processes that maintain and express genetic systems. For DNA, the maintenance, replication, and transcription processes are accomplished purely by protein , not by self-catalysis. However, the processes of gene expression via splicing and protein synthesis are catalyzed by RNP complexes (the and ).

This difference between protein and ribonucleoprotein catalysts can be explained by extending the theory. The older RNA molecules were originally self-catalyzed through , with a single type of molecule serving both as information templates and metabolic catalysts. RNA then evolved the assistance of proteins to form RNP. Thereafter, the newer DNA molecule used only the more efficient protein processes from the start. Thus, our current DNA world could have resulted from the gradual replacement of RNA catalysis machines with proteins. In this view, ribonucleoproteins and nucleotide-based cofactors are remnants of an intermediary era, the RNP world.


See also
  • First universal common ancestor

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